Mineralocorticoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Mineralocorticoid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCCS, APOH, and TBC1D13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HCCS grouped by Mineralocorticoid biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HCCS →	+0.250	+0.805	.003	.006	2	5
LIVER	APOH →	-0.148	-1.756	.005	.005	3	4
LUNG_SCLC	TBC1D13 →	+0.242	+1.330	<.001	<.001	3	3
LUNG_NSCLC_LUSC	CEBPE →	-0.167	-0.238	<.001	<.001	3	3
BONE	RAB36 →	-0.342	-1.621	.002	.001	3	3
BONE	LPA →	-0.210	-2.639	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HCCS by Mineralocorticoid biosynthetic process activity — BREAST

Explore this box plot interactively →