Estrogen biosynthetic process

Across TCGA patient cohorts, RNA activity of the Estrogen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGST3, SLC35B3, and MKRN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Estrogen biosynthetic process activity versus MGST3 in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MGST3 →	+0.234	+0.073	<.001	<.001	3	5
COAD	SLC35B3 →	+0.262	+0.115	.008	.002	2	5
COAD	MKRN1 →	+0.257	+0.114	<.001	.002	2	5
COAD	GLCE →	+0.503	+0.145	.001	<.001	3	4
COAD	SOWAHB →	+0.492	+0.121	.001	<.001	3	4
COAD	CLEC5A →	-0.806	-0.100	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006703 vs MGST3 — GBM

Explore this scatter interactively →