Estrogen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Estrogen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP6, NABP1, and OXTR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGFBP6 grouped by Estrogen biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IGFBP6 →	-2.736	-1.016	<.001	.005	3	5
LARGE_INTESTINE	NABP1 →	-1.502	-0.836	.001	.003	3	5
KIDNEY	OXTR →	-1.863	-1.042	<.001	<.001	3	5
SOFT_TISSUE	OPTN →	-2.055	-1.434	.004	<.001	2	5
SKIN	RRAS →	-1.988	-1.001	<.001	.002	3	4
SKIN	MDM2 →	+1.085	+0.796	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFBP6 by Estrogen biosynthetic process activity — SKIN

Explore this box plot interactively →