Estrogen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Estrogen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS11, HSD17B8, and AFF4, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Estrogen biosynthetic process activity versus DHRS11 in LIVER (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DHRS11 →	+1.373	+0.250	.001	<.001	3	14
BONE	HSD17B8 →	+1.844	+0.192	<.001	<.001	3	12
PANCREAS	AFF4 →	-0.892	-0.122	.001	.003	3	12
LUNG_NSCLC_LUSC	SLC29A2 →	+2.090	+0.215	<.001	<.001	3	10
LUNG_SCLC	FAM13B →	-0.848	-0.164	<.001	<.001	3	10
LUNG_NSCLC_LUSC	RECQL →	-1.194	-0.179	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006703 vs DHRS11 — LIVER

Explore this scatter interactively →