Estrogen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Estrogen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R18, SMURF2, and PHAX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Estrogen biosynthetic process activity versus PPP1R18 in CNS (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PPP1R18 →	-0.630	-0.930	.006	.004	3	6
SKIN	SMURF2 →	-1.332	-0.880	<.001	.005	2	5
CNS	PHAX →	-0.652	-1.231	.004	.001	3	4
BLOOD_Lymphoma	TUT1 →	+0.542	+0.562	<.001	.002	3	4
STOMACH	DNHD1 →	+1.519	+1.495	.002	.003	3	4
STOMACH	C11orf54 →	+1.440	+1.530	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006703 vs PPP1R18 — CNS

Explore this scatter interactively →