Androgen biosynthetic process

Across TCGA patient cohorts, RNA activity of the Androgen biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are P4HA2, COLGALT1, and CORO1C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen biosynthetic process activity versus P4HA2 in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	P4HA2 →	+0.613	+0.101	<.001	<.001	3	6
OV	COLGALT1 →	+0.491	+0.067	<.001	<.001	3	5
OV	CORO1C →	+0.399	+0.055	.007	.003	3	5
OV	RUNX1 →	+0.510	+0.052	<.001	<.001	3	5
OV	CNN2 →	+0.732	+0.051	<.001	<.001	3	5
OV	CRTAP →	+0.496	+0.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006702 vs P4HA2 — GBM

Explore this scatter interactively →