Androgen biosynthetic process

Across TCGA patient cohorts, RNA activity of the Androgen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM43B, TRAJ4, and LSM5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen biosynthetic process activity versus TRIM43B in LUAD (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIM43B →	-0.021	-0.632	.006	.004	3	3
LSCC	TRAJ4 →	-0.780	-0.476	.001	.007	3	3
HNSC	LSM5 →	+0.382	+0.129	.007	.001	3	2
HNSC	FNDC7 →	+0.124	+0.099	.002	.003	3	2
HNSC	ABLIM3 →	-0.624	-0.158	<.001	.009	3	2
HNSC	HSD3BP3 →	+0.331	+0.102	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006702 vs TRIM43B — LUAD

Explore this scatter interactively →