Androgen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Androgen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MROH6, EMP3, and ADGRA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MROH6 grouped by Androgen biosynthetic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MROH6 →	+0.850	+1.364	.002	.002	3	6
LUNG_NSCLC_LUAD	EMP3 →	-2.204	-0.851	.004	.006	3	5
CNS	ADGRA2 →	-1.544	-0.825	.003	.008	3	5
LUNG_NSCLC_LUAD	SPTBN2 →	+1.650	+1.165	<.001	<.001	3	5
OESOPHAGUS	AKAP8L →	-0.823	-1.633	.004	<.001	3	5
STOMACH	MAP7D1 →	-0.968	-1.414	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MROH6 by Androgen biosynthetic process activity — KIDNEY

Explore this box plot interactively →