Androgen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Androgen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMURF2, CACNB1, and MT2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen biosynthetic process activity versus SMURF2 in LUNG_NSCLC_LUAD (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMURF2 →	-1.493	-0.684	.001	.002	3	4
BLOOD_Myeloma	CACNB1 →	-1.560	-0.562	.006	.009	2	4
LUNG_NSCLC_LUAD	MT2A →	-1.996	-0.649	.007	.001	3	3
LUNG_NSCLC_LUAD	CCNG2 →	-1.297	-0.598	<.001	.006	3	3
LUNG_NSCLC_LUAD	PGD →	+1.309	+0.611	<.001	<.001	3	3
LUNG_NSCLC_LUAD	CYB5R2 →	+1.379	+0.511	.009	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006702 vs SMURF2 — LUNG_NSCLC_LUAD

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