Progesterone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Progesterone biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALD1_S789, C1R, and ARAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Progesterone biosynthetic process activity versus CALD1_S789 in PDAC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CALD1_S789 →	+0.664	+0.057	.006	.005	3	6
BRCA	C1R →	+0.474	+0.088	<.001	<.001	3	5
GBM	ARAP1 →	+0.284	+0.088	<.001	<.001	3	5
UCEC	MAP1B_S1265 →	+0.566	+0.083	.004	.002	3	5
UCEC	NOP58 →	-0.184	-0.057	<.001	.008	3	5
PDAC	DKC1 →	-0.148	-0.067	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006701 vs CALD1_S789 — PDAC

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