Progesterone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Progesterone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RMND5A, MCUB, and ERCC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Progesterone biosynthetic process activity versus RMND5A in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RMND5A →	-0.474	-0.905	.004	<.001	3	4
LSCC	MCUB →	+0.263	+0.371	.007	.001	3	4
COAD	ERCC1 →	-0.466	-0.516	.009	.002	3	3
COAD	APCDD1 →	-2.108	-0.531	.003	.001	3	3
COAD	DDHD2 →	-0.903	-0.606	<.001	.007	3	3
GBM	INTS9 →	-0.233	-0.588	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006701 vs RMND5A — BRCA

Explore this scatter interactively →