C21-steroid hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the C21-steroid hormone biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IGFBP7, PCOLCE, and MPRIP_S619, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C21-steroid hormone biosynthetic process activity versus IGFBP7 in GBM (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IGFBP7 →	+0.583	+0.053	.001	.005	3	8
CCRCC	PCOLCE →	+0.872	+0.080	<.001	<.001	3	8
CCRCC	MPRIP_S619 →	+0.445	+0.059	<.001	<.001	3	7
HNSC	PLS3 →	+0.563	+0.071	<.001	<.001	3	7
BRCA	SRPX2 →	+1.096	+0.058	<.001	<.001	3	6
BRCA	AEBP1 →	+0.877	+0.058	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006700 vs IGFBP7 — GBM

Explore this scatter interactively →