C21-steroid hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the C21-steroid hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F13A1, DAB2, and FOLR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C21-steroid hormone biosynthetic process activity versus F13A1 in GBM (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	F13A1 →	+1.743	+0.890	<.001	<.001	3	5
GBM	DAB2 →	+0.848	+0.527	<.001	<.001	3	5
GBM	FOLR2 →	+1.314	+0.676	<.001	<.001	3	5
LUAD	POLR1C →	-0.325	-0.403	.002	.002	3	5
BRCA	MAF →	+0.589	+0.629	<.001	<.001	3	5
GBM	IL10 →	+0.597	+0.572	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006700 vs F13A1 — GBM

Explore this scatter interactively →