C21-steroid hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the C21-steroid hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL6A2, SYT17, and OPTN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COL6A2 grouped by C21-steroid hormone biosynthetic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	COL6A2 →	-3.414	-1.732	.006	<.001	2	6
CNS	SYT17 →	+0.809	+0.836	.001	.001	3	5
BONE	OPTN →	-2.657	-1.901	.008	<.001	2	6
BONE	NLRC5 →	-3.166	-1.901	.002	<.001	3	5
CNS	H6PD →	-1.103	-1.387	<.001	<.001	3	5
STOMACH	C3orf18 →	-1.321	-1.734	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COL6A2 by C21-steroid hormone biosynthetic process activity — BONE

Explore this box plot interactively →