C21-steroid hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the C21-steroid hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG4D, TBC1D19, and PGD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C21-steroid hormone biosynthetic process activity versus ATG4D in LUNG_SCLC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATG4D →	+1.095	+0.174	<.001	.008	3	6
SKIN	TBC1D19 →	+1.026	+0.221	.009	.009	2	6
BLOOD_Lymphoma	PGD →	+0.593	+0.156	.008	.004	2	6
SOFT_TISSUE	LRP12 →	+1.212	+0.252	.002	.005	3	5
KIDNEY	SPPL2A →	+1.132	+0.202	.001	.004	3	4
LUNG_NSCLC_LUAD	AKR1C3 →	+4.674	+0.371	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006700 vs ATG4D — LUNG_SCLC

Explore this scatter interactively →