Prostanoid metabolic process

Across TCGA patient cohorts, RNA activity of the Prostanoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF8, SYNPO, and CHERP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostanoid metabolic process activity versus PRPF8 in LSCC (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRPF8 →	-0.292	-0.076	<.001	<.001	3	8
BRCA	SYNPO →	+0.322	+0.031	<.001	<.001	3	7
LSCC	CHERP →	-0.289	-0.056	.001	.001	3	7
UCEC	SCAF11 →	-0.253	-0.067	<.001	<.001	3	7
LSCC	SNRNP200 →	-0.333	-0.073	<.001	<.001	3	7
LSCC	SRSF11 →	-0.307	-0.071	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006692 vs PRPF8 — LSCC

Explore this scatter interactively →