Prostanoid metabolic process

Across TCGA patient cohorts, RNA activity of the Prostanoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PTGS2, and IGHA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostanoid metabolic process activity versus PLA2G4A in COAD (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G4A →	+1.403	+0.169	<.001	<.001	3	6
LSCC	PTGS2 →	+1.439	+0.191	<.001	<.001	2	6
GBM	IGHA1 →	+2.204	+0.204	<.001	<.001	3	5
OV	MS4A2 →	+0.368	+0.144	<.001	.006	3	5
UCEC	CH25H →	+1.027	+0.281	<.001	<.001	3	5
CCRCC	SLC16A7 →	+0.651	+0.193	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006692 vs PLA2G4A — COAD

Explore this scatter interactively →