Prostanoid metabolic process

Across TCGA cell cohorts, RNA activity of the Prostanoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B1, GRAMD2B, and POLRMT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostanoid metabolic process activity versus AKR1B1 in BLOOD_Leukemia (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AKR1B1 →	+2.190	+0.179	.002	.009	2	6
LUNG_NSCLC_LUAD	GRAMD2B →	-1.318	-0.263	<.001	<.001	3	5
SOFT_TISSUE	POLRMT →	+0.687	+0.233	<.001	.007	3	5
PANCREAS	ATP6AP1 →	-0.851	-0.324	.007	.001	3	4
BLOOD_Leukemia	CYB561 →	-1.973	-0.219	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ARTN →	-1.567	-0.312	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006692 vs AKR1B1 — BLOOD_Leukemia

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