Leukotriene metabolic process

Across TCGA patient cohorts, RNA activity of the Leukotriene metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PTGS2, and CARD6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene metabolic process activity versus PLA2G4A in UCEC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLA2G4A →	+2.032	+0.318	<.001	<.001	3	9
LUAD	PTGS2 →	+1.756	+0.149	<.001	<.001	3	7
LSCC	CARD6 →	+0.800	+0.210	<.001	<.001	3	5
GBM	CTSB →	+0.787	+0.179	<.001	.002	3	5
BRCA	LYZ →	+1.198	+0.187	.002	.004	3	5
LSCC	RAD51AP1 →	-0.740	-0.150	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006691 vs PLA2G4A — UCEC

Explore this scatter interactively →