Leukotriene metabolic process

Across TCGA cell cohorts, RNA activity of the Leukotriene metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTNAP3B, PIP5KL1, and ICA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene metabolic process activity versus CNTNAP3B in OESOPHAGUS (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CNTNAP3B →	-1.372	-1.063	.003	.003	3	5
BLOOD_Myeloma	PIP5KL1 →	-1.670	-1.271	<.001	<.001	3	4
SKIN	ICA1 →	-2.285	-0.745	<.001	.008	3	4
LARGE_INTESTINE	COX16 →	+0.638	+1.066	.002	.002	3	4
BLOOD_Lymphoma	CD96 →	-1.303	-0.638	.006	.007	3	4
BONE	MFAP3L →	-2.104	-1.965	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006691 vs CNTNAP3B — OESOPHAGUS

Explore this scatter interactively →