Icosanoid metabolic process

Across TCGA patient cohorts, RNA activity of the Icosanoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBPC3, CD36, and NUP35, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid metabolic process activity versus MYBPC3 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYBPC3 →	+0.250	+0.228	.001	<.001	3	6
OV	CD36 →	+1.241	+0.209	.006	.001	3	6
OV	NUP35 →	-0.397	-0.179	.002	<.001	3	6
OV	WAS →	+0.882	+0.210	<.001	<.001	3	5
UCEC	NIF3L1 →	-0.478	-0.234	<.001	<.001	3	5
GBM	CEACAM4 →	+0.713	+0.225	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006690 vs MYBPC3 — GBM

Explore this scatter interactively →