Icosanoid metabolic process

Across TCGA cell cohorts, RNA activity of the Icosanoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCD, ARHGAP29, and WDR46, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCD grouped by Icosanoid metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRKCD →	-1.315	-1.119	.001	.005	3	4
URINARY_TRACT	ARHGAP29 →	+1.673	+1.693	.001	<.001	3	4
URINARY_TRACT	WDR46 →	+0.687	+1.841	<.001	<.001	3	4
URINARY_TRACT	FGFR3 →	-3.753	-1.739	.005	<.001	3	4
LIVER	IFTAP →	+1.290	+1.268	.006	.006	2	5
LUNG_NSCLC_LUSC	DCAF13 →	+0.889	+1.276	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCD by Icosanoid metabolic process activity — PANCREAS

Explore this box plot interactively →