Icosanoid metabolic process

Across TCGA cell cohorts, RNA activity of the Icosanoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2AK2, AKR1C1, and LAMC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid metabolic process activity versus EIF2AK2 in LARGE_INTESTINE (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF2AK2 →	-0.684	-0.152	.001	<.001	3	6
URINARY_TRACT	AKR1C1 →	+3.880	+0.530	.009	.001	3	5
URINARY_TRACT	LAMC2 →	-3.981	-0.351	.003	.003	3	5
URINARY_TRACT	VAMP1 →	+1.137	+0.278	.002	.001	3	5
LIVER	CDK5RAP2 →	+1.107	+0.328	.009	.003	3	4
LIVER	GRAMD2B →	-1.588	-0.449	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006690 vs EIF2AK2 — LARGE_INTESTINE

Explore this scatter interactively →