Icosanoid metabolic process

Across TCGA cell cohorts, RNA activity of the Icosanoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CBR1, LTA4H, and MDH1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid metabolic process activity versus CBR1 in URINARY_TRACT (Pearson r = 0.84).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CBR1 →	+2.550	+0.492	<.001	.003	3	12
UPPER_AERODIGESTIVE_TRACT	LTA4H →	+1.271	+0.267	<.001	<.001	3	11
LUNG_NSCLC_LUSC	MDH1 →	+1.635	+0.468	.002	<.001	3	11
URINARY_TRACT	AKR1B1 →	+4.522	+0.548	<.001	.003	3	11
URINARY_TRACT	TKT →	+4.374	+0.521	<.001	.006	3	11
URINARY_TRACT	CAND1 →	+2.134	+0.509	<.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006690 vs CBR1 — URINARY_TRACT

Explore this scatter interactively →