Ganglioside catabolic process

Across TCGA patient cohorts, RNA activity of the Ganglioside catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRPM2_S38, ARHGAP4, and CTSZ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglioside catabolic process activity versus TRPM2_S38 in CCRCC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TRPM2_S38 →	+0.661	+0.062	<.001	<.001	3	6
CCRCC	ARHGAP4 →	+0.333	+0.058	.006	<.001	3	6
CCRCC	CTSZ →	+0.377	+0.050	<.001	<.001	3	6
LSCC	ANKRD44 →	+0.309	+0.055	.001	<.001	3	6
LSCC	AIF1 →	+0.353	+0.047	.005	.002	3	6
LSCC	KCTD12 →	+0.312	+0.061	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006689 vs TRPM2_S38 — CCRCC

Explore this scatter interactively →