Ganglioside catabolic process

Across TCGA patient cohorts, RNA activity of the Ganglioside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEU1, CTSA, and MTERF4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglioside catabolic process activity versus NEU1 in LUAD (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NEU1 →	+0.638	+0.115	<.001	<.001	3	7
CCRCC	CTSA →	+0.724	+0.111	<.001	<.001	3	4
GBM	MTERF4 →	-0.314	-0.119	<.001	<.001	3	4
CCRCC	SRSF8 →	-0.265	-0.072	.001	.002	3	4
GBM	MASP2 →	-0.525	-0.080	<.001	.004	3	4
PDAC	NRADDP →	-0.364	-0.037	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006689 vs NEU1 — LUAD

Explore this scatter interactively →