Ganglioside catabolic process

Across TCGA cell cohorts, RNA activity of the Ganglioside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM214A, NAV3, and FKBP8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM214A grouped by Ganglioside catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM214A →	+0.928	+0.935	.002	.006	3	4
STOMACH	NAV3 →	-2.108	-2.002	.003	<.001	3	4
LUNG_NSCLC_LUAD	FKBP8 →	+0.737	+1.141	<.001	<.001	3	3
LUNG_NSCLC_LUAD	FAM193B →	+0.673	+0.974	.006	.004	3	3
LIVER	AJM1 →	+0.749	+1.643	.003	.001	3	3
LUNG_NSCLC_LUAD	HOXA10 →	-1.122	-0.724	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM214A by Ganglioside catabolic process activity — LUNG_SCLC

Explore this box plot interactively →