Ganglioside catabolic process

Across TCGA cell cohorts, RNA activity of the Ganglioside catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLSCR2, LITAF, and TBL1X, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLSCR2 grouped by Ganglioside catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLSCR2 →	+0.108	+0.095	.008	.007	3	5
LUNG_SCLC	LITAF →	-0.393	-0.194	<.001	.002	3	5
URINARY_TRACT	TBL1X →	-0.333	-0.213	.004	<.001	3	4
SOFT_TISSUE	RAET1L →	+0.361	+0.187	<.001	.007	3	4
LARGE_INTESTINE	GSTZ1 →	-0.213	-0.147	<.001	.002	3	4
BLOOD_Leukemia	TTC1 →	-0.449	-0.236	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLSCR2 by Ganglioside catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →