Ganglioside catabolic process

Across TCGA cell cohorts, RNA activity of the Ganglioside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLB1, CTSA, and SUMF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ganglioside catabolic process activity versus GLB1 in STOMACH (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GLB1 →	+0.899	+0.887	.001	.007	3	7
LUNG_SCLC	CTSA →	+1.492	+1.580	<.001	<.001	3	7
BONE	SUMF1 →	+1.364	+1.613	<.001	.001	3	7
SKIN	NEU1 →	+1.030	+0.401	.003	<.001	3	6
BLOOD_Leukemia	DUSP3 →	+1.701	+1.135	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	QPCT →	+1.962	+1.036	<.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006689 vs GLB1 — STOMACH

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