Glycosphingolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glycosphingolipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMEM43, PLCB1, and STARD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosphingolipid biosynthetic process activity versus TMEM43 in BRCA (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMEM43 →	-0.358	-0.023	.004	.005	3	5
GBM	PLCB1 →	+0.594	+0.066	<.001	<.001	3	5
BRCA	STARD3 →	-0.414	-0.020	.004	.002	3	4
BRCA	ACTN1 →	-0.293	-0.023	<.001	<.001	3	4
BRCA	C2CD5 →	+0.218	+0.019	<.001	.003	3	4
BRCA	EFEMP2 →	-0.469	-0.025	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006688 vs TMEM43 — BRCA

Explore this scatter interactively →