Glycosphingolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycosphingolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL3, ST6GALNAC4, and ZEB1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosphingolipid biosynthetic process activity versus ST3GAL3 in LUNG_NSCLC_LUAD (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ST3GAL3 →	+1.264	+0.078	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	ST6GALNAC4 →	+1.306	+0.062	<.001	.002	3	9
URINARY_TRACT	ZEB1 →	+1.856	+0.061	.001	.001	3	9
LUNG_NSCLC_LUAD	ST3GAL2 →	+1.215	+0.051	<.001	<.001	3	8
LUNG_NSCLC_LUAD	ZNF165 →	-0.922	-0.067	<.001	<.001	3	7
PANCREAS	CLIP2 →	+1.429	+0.077	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006688 vs ST3GAL3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →