Glycosphingolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycosphingolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FURIN, SLC39A14, and PAQR7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosphingolipid biosynthetic process activity versus FURIN in BLOOD_Leukemia (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FURIN →	+1.525	+1.000	<.001	<.001	3	4
BLOOD_Leukemia	SLC39A14 →	+1.059	+0.657	.001	.009	3	4
BLOOD_Leukemia	PAQR7 →	+1.093	+0.661	.001	.006	3	4
BLOOD_Leukemia	RNFT1 →	+0.901	+0.893	.003	<.001	3	3
BLOOD_Leukemia	TXNIP →	+1.722	+0.869	<.001	.002	3	3
BLOOD_Leukemia	CD38 →	-2.665	-0.970	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006688 vs FURIN — BLOOD_Leukemia

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