Glycosphingolipid metabolic process

Across TCGA patient cohorts, RNA activity of the Glycosphingolipid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOC4L, RENBP, and ATP6V1F, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosphingolipid metabolic process activity versus NOC4L in BRCA (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NOC4L →	-0.253	-0.022	.003	.001	3	6
COAD	RENBP →	+0.534	+0.027	<.001	<.001	3	5
GBM	ATP6V1F →	+0.292	+0.046	<.001	<.001	3	5
COAD	TBRG4 →	-0.377	-0.017	<.001	<.001	3	5
COAD	UCHL1 →	+0.761	+0.032	<.001	<.001	3	5
BRCA	UTP20 →	-0.269	-0.025	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006687 vs NOC4L — BRCA

Explore this scatter interactively →