Glycosphingolipid metabolic process

Across TCGA cell cohorts, RNA activity of the Glycosphingolipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP69, ACTR10, and CEP63, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFP69 grouped by Glycosphingolipid metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZFP69 →	-1.111	-1.231	.002	.006	3	4
PANCREAS	ACTR10 →	-0.704	-1.401	.001	<.001	3	4
URINARY_TRACT	CEP63 →	+0.599	+1.934	.006	<.001	3	4
BREAST	LYRM1 →	-0.857	-0.867	.002	.004	3	3
BREAST	JSRP1 →	+0.415	+0.674	.004	.003	3	3
BREAST	EIF3F →	-0.816	-1.246	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFP69 by Glycosphingolipid metabolic process activity — STOMACH

Explore this box plot interactively →