Glycosphingolipid metabolic process

Across TCGA cell cohorts, RNA activity of the Glycosphingolipid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB21, MBD3L1, and CLVS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB21 grouped by Glycosphingolipid metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RAB21 →	-0.315	-0.085	.003	.004	3	5
LUNG_SCLC	MBD3L1 →	-0.435	-0.125	.002	<.001	3	5
LUNG_SCLC	CLVS2 →	-0.524	-0.135	<.001	<.001	3	5
BONE	NR5A2 →	-0.266	-0.137	.003	.004	3	4
BLOOD_Myeloma	KCNK10 →	-0.260	-0.064	.001	.002	3	4
LUNG_NSCLC_LUSC	CWC27 →	-0.338	-0.133	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB21 by Glycosphingolipid metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →