Glycosphingolipid metabolic process

Across TCGA cell cohorts, RNA activity of the Glycosphingolipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLB1, CCDC138, and CST3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosphingolipid metabolic process activity versus GLB1 in LUNG_SCLC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GLB1 →	+0.926	+0.928	<.001	<.001	3	6
BLOOD_Leukemia	CCDC138 →	-1.227	-1.142	<.001	.002	3	6
BLOOD_Leukemia	CST3 →	+3.340	+1.147	<.001	.001	3	6
LUNG_NSCLC_LUAD	ATP6AP1 →	+0.817	+0.418	.002	.009	3	5
LUNG_SCLC	PLXNB2 →	+1.101	+0.957	.002	.001	3	5
BLOOD_Leukemia	HEXA →	+0.746	+1.331	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006687 vs GLB1 — LUNG_SCLC

Explore this scatter interactively →