Sphingomyelin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Sphingomyelin biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADD1_S481, EPB41L2_S87, and SH3D19, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingomyelin biosynthetic process activity versus ADD1_S481 in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADD1_S481 →	+0.687	+0.064	<.001	<.001	3	7
OV	EPB41L2_S87 →	+0.788	+0.038	<.001	<.001	3	6
BRCA	SH3D19 →	+0.342	+0.031	<.001	<.001	3	5
GBM	SPTAN1 →	+0.250	+0.058	.001	<.001	3	5
LUAD	CHEK2 →	-0.342	-0.037	.002	.008	3	5
LSCC	EIF2B1 →	-0.155	-0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006686 vs ADD1_S481 — LSCC

Explore this scatter interactively →