Sphingomyelin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Sphingomyelin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF713, TRPM2, and ZSCAN31, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF713 grouped by Sphingomyelin biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF713 →	-0.854	-1.130	.001	.001	3	4
BLOOD_Myeloma	TRPM2 →	-2.452	-1.820	<.001	<.001	3	4
SOFT_TISSUE	ZSCAN31 →	-0.478	-1.479	.002	<.001	2	5
BLOOD_Myeloma	PDIA6 →	+0.936	+1.587	.003	<.001	3	3
LIVER	ANAPC5 →	-0.481	-1.460	<.001	.001	3	3
STOMACH	ZNF525 →	-2.213	-1.329	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF713 by Sphingomyelin biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →