Sphingomyelin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Sphingomyelin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA9, DBI, and PCF11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingomyelin biosynthetic process activity versus ANXA9 in PANCREAS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ANXA9 →	+1.937	+0.135	.002	.005	3	5
STOMACH	DBI →	-1.130	-0.126	.004	.009	3	5
BONE	PCF11 →	+0.762	+0.248	.007	.001	3	5
STOMACH	C1QBP →	-0.951	-0.150	.003	.001	3	5
BREAST	MUC20 →	+1.615	+0.117	.004	.001	3	5
BLOOD_Leukemia	HARBI1 →	+0.617	+0.160	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006686 vs ANXA9 — PANCREAS

Explore this scatter interactively →