Sphingomyelin catabolic process

Across TCGA patient cohorts, RNA activity of the Sphingomyelin catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASCC3, SDCCAG8, and CCDC186, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingomyelin catabolic process activity versus ASCC3 in CCRCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ASCC3 →	+0.153	+0.057	.002	.006	3	6
LSCC	SDCCAG8 →	+0.200	+0.084	<.001	<.001	3	5
GBM	CCDC186 →	+0.220	+0.079	<.001	.001	3	5
OV	NRBF2 →	+0.472	+0.081	.001	<.001	3	5
LSCC	LIMA1_S132 →	+0.303	+0.073	<.001	<.001	3	5
PDAC	TACC2_S473 →	+0.883	+0.070	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006685 vs ASCC3 — CCRCC

Explore this scatter interactively →