Sphingomyelin catabolic process

Across TCGA patient cohorts, RNA activity of the Sphingomyelin catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSS2, TAF4B, and OSMR, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingomyelin catabolic process activity versus ACSS2 in PDAC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ACSS2 →	+0.301	+0.305	.009	.009	3	3
PDAC	TAF4B →	-0.430	-0.449	.004	.001	3	3
PDAC	OSMR →	-0.538	-0.522	<.001	<.001	3	3
BRCA	FOXD3-AS1 →	-1.274	-0.484	<.001	<.001	3	3
GBM	UNC13D →	+0.415	+0.277	<.001	.003	3	3
LSCC	WDR62 →	-0.525	-0.446	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006685 vs ACSS2 — PDAC

Explore this scatter interactively →