Sphingomyelin metabolic process

Across TCGA patient cohorts, RNA activity of the Sphingomyelin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK2_S890, RPS5, and BBS7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingomyelin metabolic process activity versus ANK2_S890 in LSCC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANK2_S890 →	+0.680	+0.052	<.001	<.001	3	6
HNSC	RPS5 →	-0.172	-0.061	.001	.004	3	5
BRCA	BBS7 →	+0.412	+0.040	<.001	<.001	3	5
HNSC	GTF2F1_T331 →	-0.526	-0.051	.008	.003	3	5
GBM	SAAL1 →	-0.446	-0.058	<.001	<.001	3	5
PDAC	SEPTIN4_S432 →	+0.716	+0.055	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006684 vs ANK2_S890 — LSCC

Explore this scatter interactively →