Sphingomyelin metabolic process

Across TCGA patient cohorts, RNA activity of the Sphingomyelin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM159, GULOP, and RN7SL182P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingomyelin metabolic process activity versus TMEM159 in LUAD (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TMEM159 →	+0.657	+0.194	.005	<.001	3	3
GBM	GULOP →	+0.356	+0.148	.001	.003	3	3
CCRCC	RN7SL182P →	+0.511	+0.269	.001	.002	3	3
OV	INTS2 →	-0.390	-0.641	.004	.004	3	3
OV	KLF13 →	-0.587	-0.854	.007	.005	3	3
LUAD	PTPN13 →	+0.858	+0.152	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006684 vs TMEM159 — LUAD

Explore this scatter interactively →