Sphingomyelin metabolic process

Across TCGA cell cohorts, RNA activity of the Sphingomyelin metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCD, SPTLC1, and MMP27, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCD grouped by Sphingomyelin metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRKCD →	-0.372	-1.400	<.001	<.001	3	7
BLOOD_Leukemia	SPTLC1 →	-0.203	-0.931	<.001	.005	3	6
LIVER	MMP27 →	-0.341	-1.932	.007	<.001	3	6
BLOOD_Lymphoma	ANKRD44 →	+0.200	+2.250	.006	<.001	3	5
OVARY	SMPDL3B →	-0.285	-1.155	<.001	<.001	3	5
SOFT_TISSUE	HTR5A →	-0.233	-1.371	.008	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCD by Sphingomyelin metabolic process activity — LUNG_SCLC

Explore this box plot interactively →