Sphingomyelin metabolic process

Across TCGA cell cohorts, RNA activity of the Sphingomyelin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP76, RALBP1, and HPRT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingomyelin metabolic process activity versus CEP76 in SKIN (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CEP76 →	+0.366	+0.158	.003	<.001	3	4
KIDNEY	RALBP1 →	+1.214	+0.206	.004	.007	3	4
OVARY	HPRT1 →	-1.320	-0.287	.006	.005	3	4
SOFT_TISSUE	DDB2 →	-1.630	-0.192	.002	.004	3	4
BLOOD_Leukemia	SPTLC1 →	+0.548	+0.111	.004	.004	2	5
OESOPHAGUS	SLC9B2 →	-0.942	-0.185	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006684 vs CEP76 — SKIN

Explore this scatter interactively →