Glucosylceramide metabolic process

Across TCGA patient cohorts, RNA activity of the Glucosylceramide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA5, FOXM1, and DCN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucosylceramide metabolic process activity versus CDCA5 in BRCA (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA5 →	-0.781	-0.153	<.001	.007	3	5
BRCA	FOXM1 →	-0.776	-0.268	.004	.001	3	4
LSCC	DCN →	+0.929	+0.250	<.001	.002	3	4
BRCA	KIF23 →	-0.620	-0.229	.003	.001	3	4
LSCC	FANCI →	-0.640	-0.162	<.001	.001	3	4
BRCA	SKA1 →	-0.672	-0.206	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006678 vs CDCA5 — BRCA

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