Glycosylceramide metabolic process

Across TCGA patient cohorts, RNA activity of the Glycosylceramide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCNY, SCAF4, and SON, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosylceramide metabolic process activity versus CCNY in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CCNY →	+0.278	+0.059	<.001	.001	3	5
GBM	SCAF4 →	-0.268	-0.079	<.001	<.001	3	4
GBM	SON →	-0.257	-0.109	<.001	<.001	3	4
LUAD	PAFAH1B2 →	+0.181	+0.066	<.001	<.001	3	4
HNSC	UGT8 →	+0.880	+0.077	<.001	<.001	3	4
HNSC	CDC42BPB →	+0.179	+0.062	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006677 vs CCNY — GBM

Explore this scatter interactively →