Glycosylceramide metabolic process

Across TCGA patient cohorts, RNA activity of the Glycosylceramide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MUC1, SPC24, and CDCA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosylceramide metabolic process activity versus MUC1 in HNSC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MUC1 →	+1.014	+0.195	.001	<.001	3	4
LSCC	SPC24 →	-0.828	-0.192	<.001	<.001	3	4
BRCA	CDCA2 →	-0.962	-0.177	<.001	<.001	3	4
BRCA	OIP5 →	-0.546	-0.159	<.001	<.001	3	4
LSCC	MCM4 →	-0.839	-0.227	<.001	<.001	3	4
LSCC	EZH2 →	-0.926	-0.215	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006677 vs MUC1 — HNSC

Explore this scatter interactively →