Glycosylceramide metabolic process

Across TCGA cell cohorts, RNA activity of the Glycosylceramide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSAD1, OVOL1, and PRKCZ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RSAD1 grouped by Glycosylceramide metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RSAD1 →	+1.083	+1.244	.002	.003	3	4
LUNG_NSCLC_LUAD	OVOL1 →	+1.362	+0.604	.002	.006	3	4
BREAST	PRKCZ →	+1.360	+1.126	.003	.003	3	4
LUNG_SCLC	YWHAE →	-0.821	-1.063	.003	.009	3	3
LUNG_SCLC	HASPIN →	-0.810	-1.189	.006	.005	3	3
OVARY	PALD1 →	-1.312	-1.239	.008	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RSAD1 by Glycosylceramide metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →