Glycosylceramide metabolic process

Across TCGA cell cohorts, RNA activity of the Glycosylceramide metabolic process pathway is significantly associated with the total protein of multiple features, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Akt, XRCC1, and ADAR1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosylceramide metabolic process activity versus Akt in LARGE_INTESTINE (Pearson r = -0.58).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Akt →	-1.155	-0.273	.002	.007	3	2
LARGE_INTESTINE	XRCC1 →	+0.097	+0.315	.027	.044	2	2
PANCREAS	ADAR1 →	+0.692	+0.569	.007	.020	3	1
PANCREAS	MDMX_MDM4 →	+0.170	+0.462	.014	.013	3	1
PANCREAS	PI3K-p110-a →	-0.404	-0.578	.022	.017	2	2
PANCREAS	ATM →	-0.659	-0.540	.018	.028	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006677 vs Akt — LARGE_INTESTINE

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